Product Description
      Mutation of lysine 63 to arginine renders ubiquitin (Ub) unable to form poly-Ub chains via lysine 63 linkages with other Ub molecules. Ub K63R can form an E1-catalyzed active thioester at the C-terminus allowing the molecule to be transferred to the lysines of substrate proteins. Ideal for the reduction in poly-Ub chain length/conjugation rates and determining if poly-Ub chains are K63 linked.